Minnesota Vikings vs San Francisco 49ers Odds, Spread & Total – Sunday, Nov 22
Vikings and 49ers meet Sunday, Nov 22 at 8:20 PM ET at Estadio Banorte in Mexico City (neutral site). 49ers is favored by 3.5 at DraftKings; the total is 45.5. At DraftKings, the total has moved from 46.5 to 45.5.
VS
Estadio Banorte
Mexico City
NBC
Weather: Mostly clear, 67°F
What to watch
- Line moveThe total moved from 46.5 to 45.5 since the opening line (DraftKings).
- InjuriesListed out for the Vikings: Kyler Murray (QB), Tyrion Ingram-Dawkins (DE) and 2 more.
- WeatherForecast near the start: Mostly clear, 67°F, wind 0 mph (gusts 16 mph), 34% chance of rain.
Facts from the data on this page at the last refresh. Odds change; this is not a prediction or betting advice.
Odds across books
| Market | DraftKingsESPN (DraftKings) |
|---|---|
| MIN spread | +3.5 -105 |
| SF spread | -3.5 -115 |
| MIN ML | +170 |
| SF ML | -205 |
| Over | O 45.5 -115 |
| Under | U 45.5 -105 |
Highlighted = best price among books legal in your state (with your state set). Odds change; confirm with the sportsbook. No Hard Rock Bet or FanDuel line for this game at the last pull.
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Line movement
Line movement · DraftKings
| Market | Open | Now | Move |
|---|---|---|---|
| Spread (SF) | -3.5 | -3.5 | no change |
| Total | 46.5 | 45.5 | -1 |
| SF moneyline | -205 | -205 | no change |
| MIN moneyline | +170 | +170 | no change |
Open = first line we recorded (Fri, Nov 13 · 12:15 AM ET). Spread shown from the SF side.
Game-day weather
Mostly clear · Mexico City, Mexico City
67°F, wind 0 mph NNW, gusts 16, 34% chance of rain.
Forecast at kickoff from Open-Meteo, as of Sat, Nov 14 · 1:15 PM ET.
Form & injuries
Records & recent form
| Team | Record | Home/Away | Last 10 | Streak | Last 5 |
|---|---|---|---|---|---|
| MIN | 6-2 | 3-1 | 6-2 | L2 | WWWLL |
| SF | 7-1 | 5-0 | 7-1 | W1 | WWWLW |
MIN: 2nd in NFC North · SF: 1st in NFC West
Home/Away = MIN on the road, SF at home.
Last five games
Vikings
- W vs Miami Dolphins 15-10
- W @ New Orleans Saints 23-13
- W vs Indianapolis Colts 16-10
- L @ Detroit Lions 19-15
- L vs Buffalo Bills 23-6
49ers
- W vs Denver Broncos 24-14
- W @ Seattle Seahawks 32-29
- W vs Washington Commanders 23-17
- L @ Atlanta Falcons 29-20
- W vs Las Vegas Raiders 38-17
Injuries
Vikings
- Kyler Murray QB Out Hamstring
- Tyrion Ingram-Dawkins DE Out Ankle
- Blake Cashman LB Out Concussion
- Jauan Jennings WR Out Calf
- Joshua Metellus S Questionable Shoulder
49ers
- Trent Williams OT Questionable Shoulder
- Renardo Green CB Questionable Back
- Deommodore Lenoir CB Questionable Foot
- Dre Greenlaw LB Questionable Knee
- Gracen Halton DT Injured Reserve Ankle
Source: ESPN injury reports at the last data refresh.
Team leaders
- Passing Yards Brock Purdy 163/236, 1,980 YDS, 17 TD, 5 INT
- Rushing Yards Christian McCaffrey 102 CAR, 457 YDS, 9 TD
- Receiving Yards George Kittle 38 REC, 483 YDS, 5 TD
- Sacks Keion White 3.5
- Tackles Fred Warner 77
- Rushing Yards Aaron Jones Sr. 115 CAR, 474 YDS, 2 TD
- Receiving Yards Justin Jefferson 31 REC, 393 YDS, 4 TD
- Sacks Andrew Van Ginkel 7.5
Out, Doubtful and injured-reserve players are left off. Questionable and day-to-day players stay, marked with a badge.
Built from LineSmart data refreshed Sat, Nov 14, 2026 · 5:45 PM ET. Odds are for reference and may change; confirm with the sportsbook. For adults 21+.